課程資訊
課程名稱
老化分子神經生物學
Molecular Neurobiology of Aging 
開課學期
107-2 
授課對象
學程  神經生物與認知科學學程  
授課教師
王培育 
課號
GIBMS7110 
課程識別碼
454 M0110 
班次
 
學分
2.0 
全/半年
半年 
必/選修
選修 
上課時間
星期一2,3(9:10~11:10) 
上課地點
基1203 
備註
與吳恩賜、黃憲松、曾明宗、姚皓傑合授
限本系所學生(含輔系、雙修生)
總人數上限:30人 
Ceiba 課程網頁
http://ceiba.ntu.edu.tw/1072GIBMS7110_ 
課程簡介影片
 
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課程概述

課程討論主題包括:1. Studies of human and animal aging, 2. Molecular mechanism of aging and neurodegenerative diseases, 3. Development of Anti-aging interventions。 

課程目標
教導學生了解老化及神經退化等相關疾病的分子機轉,並學習抗老化藥物的研發過程與進展。 
課程要求
參與論文選讀及報告。 
預期每週課後學習時數
 
Office Hours
 
指定閱讀
待補 
參考書目
(1) Molecular biology of aging, Leonard Guarente,Linda Partridge,Douglas C. Wallace, 2008
(2) Selected research papers
 
評量方式
(僅供參考)
   
課程進度
週次
日期
單元主題
第1週
2019/2/18  Mechanisms Underlying Microbial-Mediated
Changes in Social Behavior in Mouse Models of
Autism Spectrum Disorder 
第2週
2019/2/25  Gut vagal sensory signaling regulates hippocampus
function through multi-order pathways 
第3週
2019/3/4  Microbiota-Produced Succinate Improves Glucose
Homeostasis via Intestinal Gluconeogenesis 
第4週
2019/3/11  Life span extension by targeting a link
between metabolism and histone acetylation
in Drosophila 
第5週
2019/3/18  A Neuronal Relay Mediates a Nutrient Responsive
Gut/Fat Body Axis Regulating Energy Homeostasis in
Adult Drosophila 
第6週
2019/3/25  Obesity-Induced Cellular Senescence Drives Anxiety
and Impairs Neurogenesis 
第7週
2019/4/1  The Human Longevity Gene Homolog
INDY and Interleukin-6 Interact in
Hepatic Lipid Metabolism 
第8週
2019/4/8  Adult hippocampal neurogenesis is abundant in
neurologically healthy subjects and drops sharply
in patients with Alzheimer’s disease 
第9週
4/15  The Gut Microbiota Mediates the Anti-Seizure
Effects of the Ketogenic Diet 
第10週
4/22  Activation of Anxiogenic Circuits Instigates
Resistance to Diet-Induced Obesity via Increased
Energy Expenditure 
第11週
4/29  Mechanisms Preserving Insulin Action during High
Dietary Fat Intake 
第12週
5/6  Autophagy in the CNS and Periphery Coordinate
Lipophagy and Lipolysis in the Brown Adipose Tissue
and Liver 
第13週
5/13  Drosophila Histone Demethylase KDM5 Regulates
Social Behavior through Immune Control and Gut
Microbiota Maintenance 
第14週
5/20  Hepatic arginase 2 (Arg2) is sufficient to convey
the therapeutic metabolic effects of fasting 
第15週
5/27  A fat-tissue sensor couples growth to oxygen
availability by remotely controlling insulin secretion 
第16週
6/3  Serotonin modulates a depression-like state in
Drosophila responsive to lithium treatment 
第17週
6/10  Aged blood impairs hippocampal neural precursor
activity and activates microglia via brain
endothelial cell VCAM1 
第18週
6/17  Heterochronic faecal transplantation boosts gut
germinal centres in aged mice